INCLUDE Project: Exploratory/Developmental Research Awards for Down syndrome (R21 Clinical Trial Not Allowed)
Posted: May 12, 2026 12:00:00 AM EDT
Closes: 06/15/2028
Funding Information
Estimated Total Funding
$1,000,000
Award Ceiling
$200,000
Expected Number of Awards
5
Description
The NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project seeks to improve health and quality-of-life for individuals with Down syndrome. This Notice of Funding Opportunity (NOFO) invites researchers to submit applications for support of new exploratory and developmental research projects that address critical needs for Down syndrome projects, as articulated in the INCLUDE Project objectives. For example, such projects could assess the feasibility of a novel area of investigation or a new experimental system that has the potential to enhance health-related research. Another example could include the unique and innovative use of an existing methodology to explore a new scientific area. These studies may involve considerable risk but may lead to a breakthrough in a particular area, or to the development of novel techniques, agents, methodologies, models, or applications that could have a major impact on a field of biomedical, behavioral, or clinical research.
Synopsis
The NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project seeks to improve health and quality-of-life for individuals with Down syndrome. This Notice of Funding Opportunity (NOFO) invites researchers to submit applications for support of new exploratory and developmental research projects that address critical needs for Down syndrome projects, as articulated in the INCLUDE Project objectives. For example, such projects could assess the feasibility of a novel area of investigation or a new experimental system that has the potential to enhance health-related research. Another example could include the unique and innovative use of an existing methodology to explore a new scientific area. These studies may involve considerable risk but may lead to a breakthrough in a particular area, or to the development of novel techniques, agents, methodologies, models, or applications that could have a major impact on a field of biomedical, behavioral, or clinical research.
Eligibility
Eligible Applicants:
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Funding Activity Categories
CFDA Numbers
- 93.121 - Oral Diseases and Disorders Research
- 93.173 - Research Related to Deafness and Communication Disorders
- 93.233 - National Center on Sleep Disorders Research
- 93.310 - Trans-NIH Research Support
- 93.351 - Research Infrastructure Programs
- 93.395 - Cancer Treatment Research
- 93.837 - Cardiovascular Diseases Research
- 93.838 - Lung Diseases Research
- 93.839 - Blood Diseases and Resources Research
- 93.840 - Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders
- 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research
- 93.855 - Allergy and Infectious Diseases Research
- 93.865 - Child Health and Human Development Extramural Research
- 93.866 - Aging Research
- 93.867 - Vision Research
- 93.879 - Medical Library Assistance
Contact Information
Agency: National Institutes of Health
Contact: National Institutes of Health
Phone: 301-402-2541
The INCLUDE Project
DownSyndromeINCLUDE@mail.nih.gov
DownSyndromeINCLUDE@mail.nih.gov
Additional Information
Document Type: synopsis
Opportunity Category: Discretionary
Version: 1
Last Updated: May 12, 2026 11:21:18 AM EDT
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