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SBIR/STTR Commercialization Readiness Pilot (CRP) Program (Parent SB1 Clinical Trial Optional)

HHS-NIH11 PAR-27-098
Posted: May 28, 2026 12:00:00 AM EDT
Closes: 04/05/2029
Views: 77

Description

The Commercialization Readiness Pilot (CRP) program helps small business concerns (SBCs) move NIH-funded SBIR or STTR projects from late-stage development to commercialization. The CRP supports later-stage research and development (R&D) and/or technical assistance that Phase II and Phase IIB Strategic Breakthrough awards do not typically support. This includes:Independent replication or confirmation of key studiesIND- or IDE-enabling studiesClinical studiesManufacturing scale-up and related quality activitiesRegulatory and other specialized technical supportSBCs may subcontract (outsource) a significant amount of the work in a CRP to meet the project goals.

Synopsis

The Commercialization Readiness Pilot (CRP) program helps small business concerns (SBCs) move NIH-funded SBIR or STTR projects from late-stage development to commercialization. The CRP supports later-stage research and development (R&D) and/or technical assistance that Phase II and Phase IIB Strategic Breakthrough awards do not typically support. This includes:Independent replication or confirmation of key studiesIND- or IDE-enabling studiesClinical studiesManufacturing scale-up and related quality activitiesRegulatory and other specialized technical supportSBCs may subcontract (outsource) a significant amount of the work in a CRP to meet the project goals.

Eligibility

Eligible Applicants:
Others (see text field entitled "Additional Information on Eligibility" for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities Small businesses Independent school districts For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments) City or township governments County governments State governments Special district governments
Only United States small business concerns (SBCs), as defined by the Small Business Administration (SBA)(sbir.gov/apply) are eligible to submit applications for this opportunity.Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Unfunded international collaborations or unfunded foreign components, as defined in the NIH Grants Policy Statement, may be allowed.

Funding Activity Categories

Health

CFDA Numbers

  • 93.113 - Environmental Health
  • 93.121 - Oral Diseases and Disorders Research
  • 93.143 - NIEHS Superfund Hazardous Substances_Basic Research and Education
  • 93.172 - Human Genome Research
  • 93.173 - Research Related to Deafness and Communication Disorders
  • 93.233 - National Center on Sleep Disorders Research
  • 93.242 - Mental Health Research Grants
  • 93.273 - Alcohol Research Programs
  • 93.286 - Discovery and Applied Research for Technological Innovations to Improve Human Health
  • 93.307 - Minority Health and Health Disparities Research
  • 93.313 - NIH Office of Research on Women's Health
  • 93.350 - National Center for Advancing Translational Sciences
  • 93.351 - Research Infrastructure Programs
  • 93.393 - Cancer Cause and Prevention Research
  • 93.394 - Cancer Detection and Diagnosis Research
  • 93.395 - Cancer Treatment Research
  • 93.837 - Cardiovascular Diseases Research
  • 93.838 - Lung Diseases Research
  • 93.839 - Blood Diseases and Resources Research
  • 93.840 - Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders
  • 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research
  • 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research
  • 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders
  • 93.855 - Allergy and Infectious Diseases Research
  • 93.859 - Biomedical Research and Research Training
  • 93.865 - Child Health and Human Development Extramural Research
  • 93.866 - Aging Research
  • 93.867 - Vision Research

Contact Information

Agency: National Institutes of Health
Contact: National Institutes of Health
Email: SEEDinfo@nih.gov
Phone: 301-402-2541
NIH SEED (Small business Education and Entrepreneurial Development)
SEEDinfo@nih.gov

Additional Information

Document Type: synopsis
Opportunity Category: Discretionary
Version: 2
Last Updated: Jun 01, 2026 12:57:13 PM EDT

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