Addressing Methodological Challenges with Clinical Trials of Rapid-Acting Psychotropic Interventional Drugs (RAPIDs) (R01 Clinical Trial Required)
Posted: Apr 29, 2026 12:00:00 AM EDT
Closes: 10/11/2026
Funding Information
Estimated Total Funding
$5,500,000
Expected Number of Awards
5
Description
The purpose of this notice of funding opportunity (NOFO) is to elucidate the key components of the therapeutic effects of rapid-acting psychotropic interventional drugs (RAPIDs) by addressing the methodological challenges involved with these clinical trials. In addition, this NOFO seeks to advance understanding of how RAPIDs and adjunctive psychosocial interventions can be optimally delivered, monitored, and sustained over time to enhance effectiveness and generalizability. The NOFO will support studies designed to enhance the rigor of RAPID clinical trial design, which will ultimately increase the interpretability of the data and the generalizability of the results.
Synopsis
The purpose of this notice of funding opportunity (NOFO) is to elucidate the key components of the therapeutic effects of rapid-acting psychotropic interventional drugs (RAPIDs) by addressing the methodological challenges involved with these clinical trials. In addition, this NOFO seeks to advance understanding of how RAPIDs and adjunctive psychosocial interventions can be optimally delivered, monitored, and sustained over time to enhance effectiveness and generalizability. The NOFO will support studies designed to enhance the rigor of RAPID clinical trial design, which will ultimately increase the interpretability of the data and the generalizability of the results.
Eligibility
Eligible Applicants:
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Funding Activity Categories
CFDA Numbers
- 93.242 - Mental Health Research Grants
- 93.279 - Drug Use and Addiction Research Programs
Contact Information
Agency: National Institutes of Health
Contact: National Institutes of Health
Email: DTRcommunications@nih.gov
Phone: 301-402-2541
Division of Translational Research
DTRcommunications@nih.gov
DTRcommunications@nih.gov
Additional Information
Document Type: synopsis
Opportunity Category: Discretionary
Version: 2
Last Updated: Apr 29, 2026 01:35:07 PM EDT
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